COMPARATIVE RELATIVE BIOAVAILABILITY STUDIES OF SIX BRANDS OF OFLOXACIN MARKETED IN ZARIA

ABSTRACT

This study was aimed at assessing the comparative bioavailability of six brands of ofloxacin marketed in Zaria.

Comparative bioavailability studies of six brands of ofloxacin marketed in Zaria was successfully conducted. Quality assessment was conducted on the randomly selected six brands of ofloxacin marketed in Zaria. Identification test, assay, weight variation, friability, disintegration time and dissolution rate were determined according to BP 2009. Cheap, simple and accurate U. V. Spectrophotometry method for analysis of ofloxacin in GAA from saliva sample at 295nm was developed and validated based on ICH guideline. Calibration curve was constructed within the range of 3-18µg/ml and validated. The developed method was then employed in the comparative bioavailability studies of six brands of ofloxacin with a washout period of one week.